chronic pain — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60003	AC1-IN-1		Adenylyl cyclase
	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).		Adenylyl cyclase
T14844	BX430		P2X Receptor , Calcium Channel
	BX430 is used for chronic pain and cardiovascular disease and it is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity.		P2X Receptor , Calcium Channel
T8711	PF-05186462	PF-05150122	Sodium Channel
	PF-05186462 (PF-05150122) is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.		Sodium Channel
T7416	WS-12		TRP/TRPV Channel
	WS-12 is a potent TRPM8 agonist that acts as a cooling agent (EC50 : 193 nM)		TRP/TRPV Channel
T1780	Parecoxib	SC 69124,Vorth-P,Valus-P	COX
	Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.		COX
T15781	LP-935509		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
	LP-935509 is highly brain-penetrant and reverses fully established pain behavior following the SNL procedure. LP-935509 is also an effective inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-...		Serine/threonin kinase , AAK1 (AP2 associated kinase 1)
T8333	Aurintricarboxylic acid	ATA,NSC-4056,NSC4056,NSC 4056	Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
	Aurintricarboxylic acid (NSC-4056) is a strong inhibitor of topoisomerases and other nucleases. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme.		Apoptosis , P2X Receptor , Influenza Virus , Topoisomerase
T31208	Dasolampanel	NGX-426,NGX 426,NGX426	GluR , iGluR
	Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine.		GluR , iGluR
T34308	Rezatomidine	AGN-203818,AGN203818,AGN 203818	Adrenergic Receptor
	Rezatomidine (AGN203818) is a selective antagonist of α2-adrenergic receptor and can be used in studies about chronic pain, including neuropathic pain.		Adrenergic Receptor
T78652	P38α inhibitor 4		p38 MAPK
	p38α inhibitor 4 is a selective MAPK p38α inhibitor, which is used to study diabetes, pain and chronic inflammation.		p38 MAPK
T0916	Butamben	Butyl 4-aminobenzoate	Potassium Channel , Calcium Channel , Sodium Channel
	Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.		Potassium Channel , Calcium Channel , Sodium Channel
T33429	MK-2295		TRP/TRPV Channel
	MK-2295 is a potent TRPV1 antagonist. MK-2295 can be used in studies about the treatment of chronic pain.		TRP/TRPV Channel
T7772	Fast Green FCF	C.I. 42053,Food green 3,FD&C Green No. 3	Others
	Fast Green FCF (FD&C Green No. 3), a safe biocompatible color additive, has been suggested to mitigate chronic pain.		Others
T19812	Propentofylline	HWA-285,Karsivan,Propentophylline,Hextol,HWA 285,HWA285	PDE
	Propentofylline (Hextol) is a methylxanthine derivative with neuroprotective, antiproliferative, and anti-inflammatory activity and enhanced synaptic adenosine signaling, which may be useful in the study of Alzheimer's d...		PDE
T3699	Bay 59-3074		Cannabinoid Receptor
	Bay 59-3074 is a CB1/CB2 receptor partial agonist (Ki: 48.3/45.5 nM). In rat models of chronic neuropathic and inflammatory pain, it displays anti-hyperalgesic and antiallodynic properties.		Cannabinoid Receptor
T72023	JB002		Myosin
	JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM. It holds potential for research applications in muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.		Myosin
T50082	Org 25543		Chloride channel
	Org 25543 is the development of an N-Acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain.		Chloride channel
T80641	Bupivacaine hydrochloride monohydrate		Potassium Channel , Calcium Channel , Sodium Channel , NMDAR
	Bupivacaine hydrochloride monohydrate is a potent NMDA receptor inhibitor of sodium, L-calcium, and potassium channels.Bupivacaine hydrochloride monohydrate inhibits SCN5A channels and is commonly used in the study of ch...
T0030L	Bupivacaine	AH 250,AH-250,AH250,Bupivacaina,Exparel,Anekain	NMDAR
	Bupivacaine (AH-250) is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the resea...		NMDAR
T1197	Trimebutine maleate	Debridat,Polibutin	Calcium Channel , Opioid Receptor
	Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors served as a spasmolytic drug for therapy of both c...		Calcium Channel , Opioid Receptor